BME Seminar Series
presents
Ana Maria Porras, PhD
Title: "Investigating the Role of the Gut Microbiome in Human Extracellular Matrix Remodeling"
Abstract:
The human extracellular matrix (ECM) is a dynamic network of proteins, glycosaminoglycans, and other molecules that provides mechanical and biochemical signals to support tissue structure and function. Dysregulation of the ECM is a hallmark of numerous diseases, including cardiac fibrosis and inflammatory bowel disease (IBD).
Traditionally, host cells such as fibroblasts and macrophages are considered the primary regulators of ECM remodeling. However, in tissues heavily colonized by microbiota, diseases characterized by high degrees of ECM remodeling like IBD, are also associated with microbiome dysfunction. Despite this, the potential role of microbiota remains largely unexplored in current models of ECM regulation.
In this talk, I will share research from our lab demonstrating that commensal gut microbes can drive ECM remodeling both locally, within the gut, and systemically, through metabolite-driven effects in distant organs. I will also highlight the in vitro approaches we are developing to study these processes in physiologically relevant contexts. Our findings challenge conventional views of ECM regulation, emphasizing the need to consider the influence of the human microbiome in pathological tissue remodeling.
Link to BME Seminar Series page with bio:
https://bme.osu.edu/events/2025/04/bme-seminar-series-ana-maria-porras-phd-university-florida
Zoom link:
https://osu.zoom.us/j/93801579842?pwd=H73sXRB74mEDrSXhPjHpwh7io58URe.1
