🚨NEW paper: Benchmarking Hi-C for virus–host inference journals.plos.org/plosbiology/... 

A clear baseline for anyone mapping virus–host interactions that establishes robust, benchmarked thresholds for Hi-C linkages. Key results: 👇

• Synthetic community (4 hosts, 9 phages) provides a ground-truth benchmark
• Raw Hi-C links: ~100% sensitivity but only ~26% specificity
• Z-score ≥0.5: specificity → ~99%, sensitivity → ~62%
• In soils: broad host links recovered, but genus/species resolution remains challenging
• Practical thresholds + guidance offered for applying Hi-C in complex microbiomes